Simplicef is a once-a-day antibiotic used to treat skin infections (wounds and abscesses) caused by susceptible strains of bacteria. Simplicef is an antibiotic belonging to a class of drugs called cephalosporins that fight bacteria in the body. Simplicef can be used to treat many different types of infections such as bronchitis or pneumonia as well as ear, skin, and urinary tract infections. It may also be used for purposes other than those listed. Simplicef requires a prescription from your veterinarian, and is sold per tablet.